2-氰基-N-(4-甲氧基苯基)乙酰胺合成路线 （共 8 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=20°C; Reflux;
参考文献
Zhou, Wei; Li, Hai-bo; Xia, Chun-nian; Zheng, Xian-ming; Hu, Wei-xiao
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 7 p. 1861 - 1865
参考文献
Schellhase; Bohm; Pech
Pharmazie, 1984 , vol. 39, # 1 p. 19 - 21
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=55°C; 22 h; Inert atmosphere;
参考文献
Oh, Sangmi; Kwon, Bosung; Kong, Sunju; Yang, Gyongseon; Lee, Nakyung; Han, Dawoon; Goo, Junghyun; Siqueira-Neto, Jair L.; Freitas-Junior, Lucio H.; Liuzzi, Michel; Lee, Jinhwa; Song, Rita
MedChemComm, 2014 , vol. 5, # 2 p. 142 - 146
反应条件
in toluene 0.0166667 h; Heating;
参考文献
Gorobets, Nikolay Yu.; Yousefi, Behrooz H.; Belaj, Ferdinand; Kappe, C. Oliver
Tetrahedron, 2004 , vol. 60, # 39 p. 8633 - 8644
反应条件
in dichloromethane Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 23 p. 4608 - 4621
反应条件
morpholine; sulfur in N,N-dimethyl-formamide T=50°C; 6 h;
参考文献
Astellas Pharma Inc.; HACHIYA, Shunichiro; MIURA, Masanori; IMAMURA, Yoshimasa; KAGA, Daisuke; SATO, Ippei; MORITOMO, Hiroyuki; KATO, Koji; TERAI, Kazuhiro; TERADA, Yoh
Patent: EP2565190 A1, 2013 ;
Location in patent: Paragraph 0129 ;
反应条件
1: 33 percent / CH3COONH4, CH3COOH / benzene / 6 h / Heating 2: 65 percent / S, Et2NH / ethanol / 3 h / 50 °C View Scheme
参考文献
Schellhase; Bohm; Pech
Pharmazie, 1984 , vol. 39, # 1 p. 19 - 21
反应条件
1: piperidine / ethanol / Heating
2: aq. HCl / dimethylformamide / 48 h / 20 °C
View Scheme
参考文献
Ukhov; Kon'shin; Odegova
Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 7 p. 364 - 365
