1 - 甲基-5 - 硝基-1H -苯并[D]咪唑合成路线 （共 18 条）
反应条件
1: 5-nitrobenzimidazole With potassium hydroxide in acetone T=0°C; 0.5 h; 2: methyl iodide in acetone T=20°C; 3 h;
参考文献
WO2006/123145 A1, ;
Page/Page column 53 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 1 h; Overall yield = 99 percent;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 13 p. 3821 - 3830
反应条件
hydrochloric acud in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Piersanti, Giovanni; Giorgi, Luca; Bartoccini, Francesca; Tarzia, Giorgio; Minetti, Patrizia; Gallo, Grazia; Giorgi, Fabrizio; Castorina, Massimo; Ghirardi, Orlando; Carminati, Paolo
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2567 - 2571
反应条件
potassium tert-butylate in N,N-dimethyl-formamide Heating;
参考文献
Tetrahedron, , vol. 46, # 17 p. 6113 - 6124
反应条件
potassium tert-butylate in N,N-dimethyl-formamide Heating;
参考文献
Bergman, Jan; Sand, Peter
Tetrahedron Letters, 1984 , vol. 25, # 18 p. 1957 - 1960
反应条件
sulfuric acid; nitric acid T=5 - 10°C;
参考文献
Journal of the Chemical Society of Pakistan, , vol. 35, # 5 p. 1343 - 1348
反应条件
1: hydrogenchloride / water 2: potassium carbonate 3: nitric acid; sulfuric acid / 5 - 10 °C View Scheme
参考文献
Journal of the Chemical Society of Pakistan, , vol. 35, # 5 p. 1343 - 1348
参考文献
Journal of Pharmacy and Pharmacology, , vol. 3, p. 420,424
反应条件
1: 40 h / 140 °C 2: H2O / 3 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 775 - 780
反应条件
1: potassium carbonate 2: nitric acid; sulfuric acid / 5 - 10 °C View Scheme
参考文献
Journal of the Chemical Society of Pakistan, , vol. 35, # 5 p. 1343 - 1348
