(2E)-3-(1-苯并噻吩-3-基)丙烯酸合成路线 （共 8 条）
反应条件
1: With piperidine; pyridine
T=110°C;
2: With hydrogenchloride in water
pH=3;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/104236 A1, 2003 ;
Location in patent: Page 179 ;
WO 03/104236 A1
反应条件
hydrogenchloride; malonic acid in pyridine; water
参考文献
Chaturvedula, Prasad V.; Chen, Ling; Civiello, Rita; Conway, Charles Mark; Degnan, Andrew P.; Dubowchik, Gene M.; Han, Xiaojun; J. Jiang, Xiang Jun; Karageorge, George N.; Luo, Guanglin; Macor, John E.; Poindexter, Graham; Tora, George; Vig, Shikha
Patent: US2004/204397 A1, 2004 ;
US 20040204397 A1
反应条件
1: 91 percent / toluene / 2 h / Heating
2: 90 percent / aq. KOH / 4 h / Heating
View Scheme
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
1: 31 percent / urotropine / CHCl3 / 1 h / Heating
2: 91 percent / toluene / 2 h / Heating
3: 90 percent / aq. KOH / 4 h / Heating
View Scheme
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
1: 74.5 percent / conc. HCl / 65 °C
2: 31 percent / urotropine / CHCl3 / 1 h / Heating
3: 91 percent / toluene / 2 h / Heating
4: 90 percent / aq. KOH / 4 h / Heating
View Scheme
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
phenylalanine ammonia-lyase in various solvent(s)
T=30°C; pH=8.8; Enzyme kinetics;
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
phenylalanine ammonia-lyase in various solvent(s)
T=30°C; pH=8.8; Enzyme kinetics;
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate
P=2585.81 Torr;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/104236 A1, 2003 ;
Location in patent: Page 179 ;
WO 03/104236 A1
