(S)-(+)-1,2,3,4-四氢-1-萘酚合成路线 （共 60 条）
反应条件
Candida antarctica lipase B in hexane T=32°C; 2.3 h;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 9 p. 1070 - 1076
反应条件
iodosylbenzene; (salen)manganese(III) complex (C104H90MnN2O2Si2(1+)*PF6(1-)) in chlorobenzene T=-20°C; 20 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 54, # 34 p. 10017 - 10028
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; Enzymatic reaction;
参考文献
Tetrahedron Letters, , vol. 45, # 3 p. 627 - 630
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: triphenyl-silyl chloride in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; Enzymatic reaction;
参考文献
Bouzemi, Nassima; Debbeche, Hanane; Aribi-Zouioueche, Louisa; Fiaud, Jean-Claude
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 627 - 630
反应条件
[(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one in toluene T=70°C; P=142.511 Torr; 68 h;
参考文献
Verzijl, Gerard K.M.; De Vries, Johannes G.; Broxterman, Quirinus B.
Tetrahedron Asymmetry, 2005 , vol. 16, # 9 p. 1603 - 1610
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(p-methylphenyl)silane in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(4-ethylphenyl)silane in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: (4-iPrC6H4)3SiCl in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: (4-iPrC6H4)3SiCl in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
