5-溴-2-苯基-1,3-噻唑合成路线 （共 15 条）
反应条件
bromine in chloroform T=20°C;
参考文献
Haemmerle, Johanna; Spina, Markus; Schnuerch, Michael; Mihovilovic, Marko D.; Stanetty, Peter
Synthesis, 2008 , # 19 art. no. T06108SS, p. 3099 - 3107
Title/Abstract Full Text View citing articles Show Details
Haemmerle, Johanna; Schnuerch, Michael; Iqbal, Naseer; Mihovilovic, Marko D.; Stanetty, Peter
Tetrahedron, 2010 , vol. 66, # 40 p. 8051 - 8059
反应条件
potassium phosphate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in tetrahydrofuran T=60°C; Suzuki coupling; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Strotman, Neil A.; Chobanian, Harry R.; He, Jiafang; Guo, Yan; Dormer, Peter G.; Jones, Christina M.; Steves, Janelle E.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1733 - 1739
反应条件
1: 79 percent / Pd(PPh3)4 / tetrahydrofuran / 12 h / 70 °C 2: 67 percent / Br2; AcONa / acetic acid / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 38 p. 7157 - 7161
反应条件
1: 99 percent / PCl3 / CHCl3 / 1.17 h / 70 °C 2: 62 percent / Br2 / CHCl3 / 20 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 46, # 4 p. 372 - 383
反应条件
1: 79 percent / Ac2O / toluene / Heating 2: 62 percent / Br2 / CHCl3 / 20 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 46, # 4 p. 372 - 383
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1.16667 h; Inert atmosphere; 2: With water in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;
参考文献
Mouri, Kazuhiro; Saito, Shohei; Yamaguchi, Shigehiro
Angewandte Chemie - International Edition, 2012 , vol. 51, # 24 p. 5971 - 5975
反应条件
cesium fluoride; tetrakis(triphenylphosphine) palladium(0) in toluene
Stille cross-coupling reaction; Heating;
参考文献
Haemmerle, Johanna; Schnuerch, Michael; Iqbal, Naseer; Mihovilovic, Marko D.; Stanetty, Peter
Tetrahedron, 2010 , vol. 66, # 40 p. 8051 - 8059
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
T=110°C; Suzuki-Miyaura coupling; 16 h;
参考文献
Haemmerle, Johanna; Schnuerch, Michael; Iqbal, Naseer; Mihovilovic, Marko D.; Stanetty, Peter
Tetrahedron, 2010 , vol. 66, # 40 p. 8051 - 8059
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in toluene
Suzuki-Miyaura coupling; 16 h; Reflux;
参考文献
Haemmerle, Johanna; Schnuerch, Michael; Iqbal, Naseer; Mihovilovic, Marko D.; Stanetty, Peter
Tetrahedron, 2010 , vol. 66, # 40 p. 8051 - 8059
反应条件
tetrakis(triphenylphosphine) palladium(0); cesium fluoride in toluene
Stille coupling; 16 h; Reflux;
参考文献
Haemmerle, Johanna; Schnuerch, Michael; Iqbal, Naseer; Mihovilovic, Marko D.; Stanetty, Peter
Tetrahedron, 2010 , vol. 66, # 40 p. 8051 - 8059
