4-氯吡啶-2,6-二羧酸甲酯合成路线 （共 30 条）
反应条件
1: ammonium hydroxide / 4.5 h / 45 °C / 3878.71 Torr / Sonication 2: N-(chloromethylene)-N-methylmethanaminium chloride; triethylamine; N,N-dimethyl-formamide / acetonitrile / 75 °C / 5171.62 Torr View Scheme
参考文献
Synthesis, , vol. 44, # 4 p. 635 - 647
参考文献
Tetrahedron Letters, , vol. 34, # 26 p. 4141 - 4144
反应条件
water; sodium hydroxide in methanol T=20°C; 1 h;
参考文献
Mueller, Sebastian; Sanders, Deborah A.; Di Antonio, Marco; Matsis, Stephanos; Riou, Jean-Francois; Rodriguez, Raphael; Balasubramanian, Shankar
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6537 - 6546
反应条件
sodium tetrahydroborate in methanol 1) 1 h, 0 deg C 2) 3 h, r.t. 3) 18 h, reflux;
参考文献
Luening, Ulrich; Baumstark, Roland; Mueller, Michael
Liebigs Annalen der Chemie, 1991 , # 10 p. 987 - 998
反应条件
sodium borohydride in ethanol; ethyl acetate
参考文献
Johnson Matthey Public Limted Company
Patent: US5698546 A1, 1997 ;
反应条件
1: 98 percent / aq. NaOH / 1 h / Heating 2: 61 percent / conc. H2SO4 / H2O / 12 h / 20 °C View Scheme
参考文献
Hamada, Yoshio; Ohta, Hiroko; Miyamoto, Naoko; Sarma, Diganta; Hamada, Takashi; Nakanishi, Tomoya; Yamasaki, Moe; Yamani, Abdellah; Ishiura, Shoichi; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2435 - 2439
反应条件
1: aq. NaOH / 80 °C 2: 43 percent / aq. H2SO4 / 120 °C 3: 83 percent / methanol / Heating 4: 91 percent / NaBH4 / CH2Cl2; methanol / 5.5 h / 0 - 20 °C 5: 88 percent / MnO2 / CH2Cl2 / 20 °C View Scheme
参考文献
Suga, Akira; Sugiyama, Toru; Otsuka, Masami; Ohno, Masaji; Sugiura, Yukio; Maeda, Kenji
Tetrahedron, 1991 , vol. 47, # 7 p. 1191 - 1204
反应条件
1: sodium ethanolate / Inert atmosphere; Reflux 2: hydrogenchloride; water / Inert atmosphere; Reflux View Scheme
参考文献
Chou, Chun-Cheng; Wu, Kuan-Lin; Chi, Yun; Hu, Wei-Ping; Yu, Shuchun Joyce; Lee, Gene-Hsiang; Lin, Chi-Li; Chou, Pi-Tai
Angewandte Chemie - International Edition, 2011 , vol. 50, # 9 p. 2054 - 2058
反应条件
1: 90 percent / hydrogen iodide; phosphorous acid / 5 h / Heating 2: 70 percent / sulfuric acid / 4 h / Heating 3: 70 percent / sodium borohydride / methanol / 17 h / Heating View Scheme
参考文献
Gilday, Lydia C.; Lang, Thomas; Caballero, Antonio; Costa, Paulo J.; Felix, Vitor; Beer, Paul D.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 16 p. 4356 - 4360
Angew. Chem., 2013 , vol. 125, # 16 p. 4452 - 4456
反应条件
ammonium hydroxide
T=150°C;
参考文献
Lamture, Jagannath B.; Wensel, Theodore G.
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4141 - 4144
