4-氯吡啶-2,6-二羧酸甲酯合成路线 （共 30 条）
反应条件
1: chelidamic acid With phosphorus pentachloride in tetrachloromethane; water 15 h; Reflux; 2: methanol in tetrachloromethane; water 4 h; Reflux;
参考文献
Nakamura, Tatsuya; Mizukami, Shin; Tanaka, Miho; Kikuchi, Kazuya
Chemistry - An Asian Journal, 2013 , vol. 8, # 11 p. 2685 - 2690
反应条件
1: chelidamic acid With phosphorus pentachloride in tetrachloromethane 6 h; Heating / reflux; 2: methanol in tetrachloromethane T=65°C; 5 h; Heating / reflux;
参考文献
US2005/245530 A1, ;
Page/Page column 83-84 ;
US 20050245530 A1
反应条件
1: chelidamic acid With N-(chloromethylene)-N-methylmethanaminium chloride; triethylamine; N,N-dimethyl-formamide in acetonitrile T=75°C; P=5171.62 Torr; 2: methanol in acetonitrile
参考文献
Battilocchio, Claudio; Baumann, Marcus; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V.; Martin, Rainer E.; Ohnmacht, Stephan A.; Tappin, Nicholas D. C.
Synthesis, 2012 , vol. 44, # 4 p. 635 - 647
反应条件
1: SOCl2 / dimethylformamide / 48 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 7 p. 1855 - 1874
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform T=0°C; 48 h; Reflux;
参考文献
Kupai, Jozsef; Huszthy, Peter; Szekely, Kata; Toth, Tuende; Parkanyic, Laszlo
Arkivoc, 2011 , vol. 2011, # 9 p. 77 - 93
反应条件
1: chelidamic acid With thionyl chloride Reflux; 2: methanol T=0 - 20°C; 2 h;
参考文献
Mueller, Sebastian; Sanders, Deborah A.; Di Antonio, Marco; Matsis, Stephanos; Riou, Jean-Francois; Rodriguez, Raphael; Balasubramanian, Shankar
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6537 - 6546
参考文献
Journal of the American Chemical Society, , vol. 78, p. 4130,4134
反应条件
1: phosphorus pentachloride / CCl4 / 4 h / Heating 2: 52.6 g / CCl4 / 1 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 61, # 7 p. 1755 - 1763
反应条件
1: thionyl chloride, dimethylformamide / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 102, # 2 p. 467 - 474
反应条件
1.1: HCl 1.2: NH3 2.1: PCl5 / CHCl3 View Scheme
参考文献
Synthetic Communications, , vol. 33, # 7 p. 1113 - 1119
