6-氯-3-甲基-1-苯基-1H-嘧啶- 2,4-二酮合成路线 （共 5 条）
反应条件
caesium carbonate in acetone
T=20°C; 16 h;
参考文献
Zeller, Joerg; Turbiak, Anjanette J.; Powelson, Ian A.; Lee, Surin; Sun, Duxin; Showalter, H.D. Hollis; Fearon, Eric R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5814 - 5820
反应条件
trichlorophosphate
T=80°C; Chlorination;
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Goto, Yuso; Obara, Fumihiro; Tsuchiya, Masami; Matsui, Junko; Hirota, Kosaku; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2037 - 2047
反应条件
1: 2N NaOH
2: c-HCl / acetic acid / 80 °C
3: POCl3 / 80 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Goto, Yuso; Obara, Fumihiro; Tsuchiya, Masami; Matsui, Junko; Hirota, Kosaku; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2037 - 2047
反应条件
1: Ac2O / acetic acid / 80 °C
2: 2N NaOH
3: c-HCl / acetic acid / 80 °C
4: POCl3 / 80 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Goto, Yuso; Obara, Fumihiro; Tsuchiya, Masami; Matsui, Junko; Hirota, Kosaku; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2037 - 2047
反应条件
1: trichlorophosphate / water / 3 h / |Reflux
2: caesium carbonate / acetone / 16 h / 20 °C
View Scheme
参考文献
Zeller, Joerg; Turbiak, Anjanette J.; Powelson, Ian A.; Lee, Surin; Sun, Duxin; Showalter, H.D. Hollis; Fearon, Eric R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5814 - 5820
