2'-溴-4-氯苯乙酮合成路线 （共 272 条）
反应条件
1: 1.2 g / KOH / dimethylformamide / 0.5 h / Ambient temperature 2: 47 percent / AcOH, piperidine / toluene / 5 h / Heating View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: 50percent NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: 2.) MeI / 1.) DMF, 80 deg C, 8 h, 2.) 80 deg C, 20 h 2: 93 percent / NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Plutitskii, D. N.; Smushkevich, Yu. I.; Suvorov, N. N.; Syubaev, R. D.; Shvarts, G. Ya.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 10 p. 733 - 737
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 10 p. 1209 - 1213
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
sodium ethanolate in diethyl ether 2 h; Heating;
参考文献
Casagrande, Manolo; Basilico, Nicoletta; Rusconi, Chiara; Taramelli, Donatella; Sparatore, Anna
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6625 - 6633
反应条件
aluminasuported sodium carbonate; silica gelsuported polyphosphoric acid in toluene T=80°C; 2 h;
参考文献
Aoyama, Tadashi; Nagaoka, Takashi; Takido, Toshio; Kodomari, Mitsuo
Synthesis, 2011 , # 4 art. no. F18910SS, p. 619 - 625
反应条件
1: 1.) sodium pellets / 1.) toluene, room temp., 3 days, 2.) toluene, 0 deg C, 1 h then room temp., 1 day 2: 49 percent / 12 M hydrochloric acid / ethanol / 24 h / Heating View Scheme
参考文献
Porretta; Scalzo; Chimenti; Bolasco; Biava; Fischetti; Riccardi
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 5 p. 629 - 639
