3-氨基-4-羟基苯甲酸甲酯合成路线 （共 42 条）
反应条件
1: aq. KOH / ethanol / Heating
2: Heating
View Scheme
参考文献
Varma; Kapoor
Pharmazie, 1979 , vol. 34, # 7 p. 387 - 389
反应条件
in tetrahydrofuran
T=0 - 20°C; 3 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2005/34941 A1, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 4-adamantylphonoxyacetic acid With oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
T=20°C; 1 h;
2: 4-hydroxy-3-amino-benzoic acid methyl ester With pyridine in tetrahydrofuran
T=20°C; Further stages.;
参考文献
DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; Lee, Kyeong; Won, Mi Sun; Kim, Hwan Mook; Park, Song Kyu; Lee, Kiho; Lee, Ki Hoon; Lee, Chang Woo; Lee, Jung Joon; Chung, Kyung Sook; Kim, Bo Kyung; Jin, Yinglan; Lee, Seung-hee
Patent: US2013/237542 A1, 2013 ;
Location in patent: Paragraph 0216; 0217; 0218 ;
反应条件
1: 4-adamantylphonoxyacetic acid With oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
T=20°C; 1 h;
2: 4-hydroxy-3-amino-benzoic acid methyl ester With pyridine in tetrahydrofuran
T=20°C;
参考文献
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
Patent: WO2008/4798 A1, 2008 ;
Location in patent: Page/Page column 30 ;
反应条件
pyridine in tetrahydrofuran
T=20°C;
参考文献
Korea Research Institute of Bioscience and Biotechnology; Dongguk University Industry-Academic Cooperation Foundation; WON, Mi-Sun; KIM, Hwan-Mook; LEE, Kyeong; PARK, Song-Kyu; LEE, Ki-Ho; LEE, Chang-Woo; LEE, Jung-Joon; CHUNG, Kyung-Sook; KIM, Bo-Kyung; JIN, Ying-Lan
Patent: WO2012/53768 A2, 2012 ;
Location in patent: Page/Page column 14-15 ;
反应条件
bromine cyanide in methanol; water
T=20°C; 0.833333 h; Cooling with ice;
参考文献
Rajyalakshmi; Reddy, A. Rama Narsimha; Sarangapani
Letters in Drug Design and Discovery, 2012 , vol. 9, # 6 p. 625 - 632
反应条件
in tetrahydrofuran
T=70°C; 4 h;
参考文献
Yamazaki, Kazuo; Kaneko, Yasushi; Suwa, Kie; Ebara, Shinji; Nakazawa, Kyoko; Yasuno, Kazuhiro
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2509 - 2522
反应条件
sulfuric acid; orthoarsenic acid
T=140 - 150°C;
参考文献
v. Niementowski; Sucharda
Chemische Berichte, 1916 , vol. 49, p. 16
参考文献
Weiss
Journal of the American Chemical Society, 1947 , vol. 69, p. 2682
反应条件
1: 96 percent / pyridine / 2 h / Heating
2: 34 percent / phosphorus oxychloride, phosphorus pentachloride / 2.5 h / 95 - 100 °C
View Scheme
参考文献
Lok, Roger; Leone, Ronald E.; Williams, Antony J.
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3289 - 3297
