8-羟基-1,2,3,4-四氢萘-2-羧酸合成路线 （共 7 条）
反应条件
boron tribromide in dichloromethane
T=-78°C; 3 h;
参考文献
Liu, Bo; Liu, Gang; Nelson, Lisa T.J.; Patel, Jyoti R.; Sham, Hing L.; Xin, Zhili; Zhao, Hongyu
Patent: US2005/14794 A1, 2005 ;
Location in patent: Page 19 ;
US 20050014794 A1
反应条件
AlCl3, aluminium chloride in toluene
2 h; RefluxInert atmosphere;
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
2: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C
2: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
3: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C
3: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C
4: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C
5: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
6: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C
2: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C
3: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C
4: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
5: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: potassium tert-butylate / tert-butyl alcohol / 2 h / 75 °C
2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C
4: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C
5: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C
6: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
7: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
