3-(3,4,5-三甲氧基苯基)-1-丙醇合成路线 （共 19 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Kato; Kido; Wu; Yoshikoshi
Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 4 p. 1516 - 1521
反应条件
1: benzene / 4 h / Reflux; Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux
View Scheme
参考文献
Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh
Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2124 - 2133
反应条件
1: thionyl chloride / dichloromethane
2: potassium carbonate / dimethyl sulfoxide / 6 h / 50 °C
3: sodium chloride / dimethyl sulfoxide / 5 h / |Reflux
4: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C / |Reflux
View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran
2: thionyl chloride / dichloromethane
3: potassium carbonate / dimethyl sulfoxide / 6 h / 50 °C
4: sodium chloride / dimethyl sulfoxide / 5 h / |Reflux
5: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C / |Reflux
View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: potassium carbonate / dimethyl sulfoxide / 6 h / 50 °C
2: sodium chloride / dimethyl sulfoxide / 5 h / |Reflux
3: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C / |Reflux
View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: sodium chloride / dimethyl sulfoxide / 5 h / |Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C / |Reflux
View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: (i) TsCl, Py, (ii) /BRN= 471171/, NaH, THF, (iii) /BRN= 1209426/, Et3N, hexane
2: KOAc, AcOH
View Scheme
参考文献
Kato; Kido; Wu; Yoshikoshi
Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 4 p. 1516 - 1521
反应条件
phosphorus tribromide in tetrahydrofuran; water; ethyl acetate
参考文献
TSUMURA and CO.
Patent: EP594890 A1, 1994 ;
反应条件
1H-imidazole; iodine; triphenylphosphine in toluene
参考文献
Rosowsky, Andre; Papoulis, Andrew T.; Queener, Sherry F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 913 - 918
