(R)-(-)-5-氧代-2-四氢呋喃羧酸合成路线 (共 11 条)
反应条件
hydrogenchloride; sodium nitrite in water T=-5 - 20°C;
参考文献
Shiro, Yuuichi; Kato, Keisuke; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki
Tetrahedron, 2006 , vol. 62, # 37 p. 8687 - 8695
参考文献
Tetrahedron: Asymmetry, , vol. 2, # 5 p. 347 - 350
反应条件
dimethylsulfide borane complex
参考文献
Harmange, Jean-Christophe; Figadere, Bruno; Hocquemiller, Reynald
Tetrahedron: Asymmetry, 1991 , vol. 2, # 5 p. 347 - 350
反应条件
in tetrahydrofuran; methanol
参考文献
Schinazi, Raymond F.; Striker, Robert; Shi, Junxing
Patent: US2004/67877 A1, 2004 ;
反应条件
1: 53 percent / BH3*Me2S / tetrahydrofuran / -20 - 20 °C 2: 93 percent / pyridine / 12 h / 20 °C View Scheme
参考文献
Shiro, Yuuichi; Kato, Keisuke; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki
Tetrahedron, 2006 , vol. 62, # 37 p. 8687 - 8695
反应条件
1: 100 percent / BH3*SMe2 2: pyridine 3: NaI, n-Bu3SnH / AIBN View Scheme
参考文献
Harmange, Jean-Christophe; Figadere, Bruno; Hocquemiller, Reynald
Tetrahedron: Asymmetry, 1991 , vol. 2, # 5 p. 347 - 350
反应条件
1: 100 percent / BH3*SMe2 2: pyridine View Scheme
参考文献
Harmange, Jean-Christophe; Figadere, Bruno; Hocquemiller, Reynald
Tetrahedron: Asymmetry, 1991 , vol. 2, # 5 p. 347 - 350
反应条件
1: 53 percent / BH3*Me2S / tetrahydrofuran / -20 - 20 °C 2: 94 percent / imidazole / dimethylformamide / 1 h / 20 °C View Scheme
参考文献
Minehan; Kishi
Angewandte Chemie - International Edition, 1999 , vol. 38, # 7 p. 923 - 925
反应条件
1.1: DCC; DMAP / CH2Cl2
2.1: BH3*THF; 2,3-dimethyl-2-butene / tetrahydrofuran
3.1: pyridine; DMAP / CH2Cl2
4.1: iodotrimethylsilane; 2,6-lutidine / CH2Cl2
5.1: NaBH4 / ethanol; CH2Cl2
5.2: 51 percent / NH3(g) / methanol
View Scheme
参考文献
Mansour, Tarek S.; Tse, Allan; Charron, Marie; Hooker, Elizabeth U.; Ashman, Clare; et al.
Medicinal Chemistry Research, 1995 , vol. 5, # 6 p. 417 - 425
反应条件
1: SOCl2 / 4 h / Heating
2: H2 / 5percent Pd/BaSO4 / toluene / 20 h / 50 °C
View Scheme
参考文献
Albrecht, Wolfgang; Tressl, Roland
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1391 - 1396