1,4-二氢-2-甲巯基-4-氧代-5-嘧啶甲酸乙酯合成路线 （共 13 条）
反应条件
1: 60 percent / dioxane / 6 h / 110 °C
2: 79 percent / phosphorus oxychloride / 0.5 h / 60 °C
3: sodium / Ambient temperature
4: NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 69 percent / dioxane / 6 h / 110 °C
2: phosphorus oxychloride / 0.5 h / 60 °C
3: 43 percent / sodium / Ambient temperature
4: NaOH / methanol; H2O / 1 h / 65 °C
5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 60 percent / dioxane / 6 h / 110 °C
2: 79 percent / phosphorus oxychloride / 0.5 h / 60 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
