1,4-二氢-2-甲巯基-4-氧代-5-嘧啶甲酸乙酯合成路线 （共 13 条）
反应条件
1: 2-methyl-2-thiopseudourea sulfate With ethanol; sodium ethanolate T=0°C; Inert atmosphere; 2: diethyl 2-ethoxymethylenemalonate in ethanol T=0 - 20°C; Inert atmosphere;
参考文献
Cho, Hidetsura; Nishimura, Yoshio; Yasui, Yoshizumi; Kobayashi, Satoshi; Yoshida, Shin-Ichiro; Kwona, Eunsang; Yamaguchi, Masahiko
Tetrahedron, 2011 , vol. 67, # 14 p. 2661 - 2669
反应条件
1: in dichloromethane T=20°C; 4 h; 2: With triethylamine
参考文献
Landreau; Deniaud; Reliquet; Meslin
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 93 - 98
参考文献
Journal of the American Chemical Society, , vol. 65, p. 350,352
反应条件
potassium hydroxide das basische Hydrojodid entsteht;
参考文献
American Chemical Journal, , vol. 37, p. 396
参考文献
Journal of the Chemical Society, , p. 4175
反应条件
1: POCl3 2: ethanol View Scheme
参考文献
Peters et al.
Cancer Research, 1959 , vol. 19, p. 729,730,731
反应条件
pyridine; hydrogen sulfide; triethylamine 4 h;
参考文献
Landreau; Deniaud; Reliquet; Meslin
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 93 - 98
反应条件
N,N-diethylaniline; trichlorophosphate 5 h; Heating / reflux;
参考文献
DECIPHERA PHARMACEUTICALS, LLC
Patent: WO2006/71940 A2, 2006 ;
Location in patent: Page/Page column 354 ;
WO 2006/071940 A2
反应条件
1: ethanol / 2 h / 160 °C / |Reflux 2: water; sodium hydroxide / methanol / 40 - 80 °C View Scheme
反应条件
1: 69 percent / dioxane / 6 h / 110 °C
2: phosphorus oxychloride / 0.5 h / 60 °C
3: 43 percent / sodium / Ambient temperature
4: NaOH / methanol; H2O / 1 h / 65 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
