3-((哌啶-1-基)甲基)-1H-吲哚合成路线 （共 19 条）
参考文献
Winthrop Chem. Co.
Patent: US2315661 , 1940 ;
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I.G. Farbenind.
Patent: DE722809 , 1939 ;
DRP/DRBP Org.Chem.
反应条件
hafnium(IV) trifluoromethanesulfonate in dichloromethane
T=20°C; 0.1 h; Inert atmosphere; regioselective reaction;
参考文献
Sakai, Norio; Shimamura, Kazuyori; Ikeda, Reiko; Konakahara, Takeo
Journal of Organic Chemistry, 2010 , vol. 75, # 11 p. 3923 - 3926
反应条件
zinc(II) chloride in ethanol
T=20°C; Mannich reaction; 1.5 h;
参考文献
Dai, Hong-Guang; Li, Ji-Tai; Li, Tong-Shuang
Synthetic Communications, 2006 , vol. 36, # 13 p. 1829 - 1835
反应条件
trimethylsilyl trifluoromethanesulfonate in methanol; dichloromethane
T=20°C; 0.5 h; Inert atmosphere; Reagent/catalyst; regioselective reaction;
参考文献
Sakai, Norio; Okano, Hidetoshi; Shimamura, Kazuyori; Konakahara, Takeo
Chemistry Letters, 2014 , vol. 43, # 4 p. 501 - 503
反应条件
trimethylsilyl iodide in dichloromethane
T=20°C; 0.5 h; Inert atmosphere; Reagent/catalystTime; regioselective reaction;
参考文献
Sakai, Norio; Okano, Hidetoshi; Shimamura, Kazuyori; Konakahara, Takeo
Chemistry Letters, 2014 , vol. 43, # 4 p. 501 - 503
反应条件
1: With n-butyllithium in hexane; toluene
T=0 - 5°C; Inert atmosphere;
2: With diisobutylaluminium hydride in hexane; toluene
T=0 - 50°C; Inert atmosphere;
参考文献
Todd, Robert; Hossain, M. Mahmun
Synthesis, 2009 , # 11 art. no. M07508SS, p. 1846 - 1850
反应条件
in methanol
T=50°C; P=6000480 Torr; 48 h;
参考文献
Matsumoto, Kiyoshi; Uchida, Takane; Hashimoto, Shiro; Yonezawa, Yukie; Iida, Hirokazu; et al.
Heterocycles, 1993 , vol. 36, # 10 p. 2215 - 2220
反应条件
aluminium trichloride in dichloromethane
3 h; Heating;
参考文献
Katritzky; Yang; Lam
Tetrahedron, 1992 , vol. 48, # 23 p. 4971 - 4978
反应条件
sodium tetrahydroborate in ethanol
3 h; Ambient temperature;
参考文献
Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1711 - 1721
反应条件
1: benzene / 1.5 h / Heating; removing the liberated water
2: 77 percent / sodium borohydride / ethanol / 3 h / Ambient temperature
View Scheme
参考文献
Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1711 - 1721
