5-(甲基硫代)苯并[d][1,3]二氧代合成路线 （共 7 条）
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 0.5 h;
2: dimethyl-disulfide in tetrahydrofuran; hexanes
0.5 h;
参考文献
CRYSTAX PHARMACEUTICALS, S.L.
Patent: WO2009/7399 A1, 2009 ;
Location in patent: Page/Page column 73 ;
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With magnesium in tetrahydrofuran
2.5 h; Heating / reflux;
2: With sulfur in tetrahydrofuran
T=-45 - 20°C; 3 h;
3: methyl iodide With hydrogenchloride; water
more than 3 stages;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2008/234314 A1, 2008 ;
Location in patent: Page/Page column 54 ;
US 20080234314 A1
反应条件
copper(l) iodide; zinc diacetate
T=135°C; 36 h; regioselective reaction;
参考文献
Joseph, P.J. Amal; Priyadarshini; Kantam, M. Lakshmi; Sreedhar
Tetrahedron, 2013 , vol. 69, # 38 p. 8276 - 8283
反应条件
1: 80 percent / acetic acid / 1 h / Ambient temperature
2: 57 percent / sodium bis(methoxyethoxy)aluminum dihydride / benzene / r.t., 1 h, then reflux, 1.5 h :new synthetic method
View Scheme
参考文献
Ruffin, L. D.; Bowlus, S. B.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 461 - 462
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in benzene
1.)r.t, 1 h 2.)reflux, 1.5 h;
参考文献
Ruffin, L. D.; Bowlus, S. B.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 461 - 462
反应条件
nitric acid; acetic anhydride
T=-10°C; 2 h;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2008/234314 A1, 2008 ;
Location in patent: Page/Page column 54 ;
US 20080234314 A1
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 0.5 h;
参考文献
CRYSTAX PHARMACEUTICALS, S.L.
Patent: WO2009/7399 A1, 2009 ;
Location in patent: Page/Page column 74 ;
