(9ci)-5-氨基-n-甲基-1H-咪唑-4-羧酰胺合成路线 （共 2 条）
反应条件
1: 63 percent / dimethylaminopyridine / pyridine / 7 h / 50 °C
2: 46 percent / Et3N / dimethylformamide / 16 h
3: 78 percent / hydrazine hydrate / ethanol / 16 h / Heating
4: acetone / 0.5 h / Heating
5: 82 percent / 0.2N aq. NaOH / 2 h
6: 93 percent / 7N aq. NaOH / dioxane / 6 h / Heating
7: 66 percent / hydrazine hydrate / ethanol / 16 h / Heating
8: 73 percent / Na / liquid ammonia
View Scheme
参考文献
Parkin; Harnden
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 1 p. 33 - 40
反应条件
sodium nitrite in water; acetic acid; ethyl acetate
参考文献
Cancer Research Campaign Technology Limited
Patent: US5260291 A1, 1993 ;
US 5260291 A
