2-对甲氧基苯基-2-甲基丙腈合成路线 （共 22 条）
反应条件
1: aq. KOH / ethane-1,2-diol / 150 °C 2: Py*HCl / 180 °C View Scheme
参考文献
CURIS, INC.
Patent: WO2009/36016 A1, 2009 ;
反应条件
1: aq. KOH / ethane-1,2-diol / Heating View Scheme
参考文献
Brown,H.C.; Kim,C.J.
Journal of the American Chemical Society, 1968 , vol. 90, p. 2082 - 2096
反应条件
potassium tert-butylate in tetrahydrofuran
T=-30 - 20°C;
参考文献
Ter Wiel, Matthijs K. J.; Odermatt, Severin; Schanen, Patrick; Seiler, Paul; Diederich, Francois
European Journal of Organic Chemistry, 2007 , # 21 p. 3449 - 3462
反应条件
P(i-BuNCH2CH2)3N; sodium hexamethyldisilazane; palladium diacetate in toluene
T=100°C; 8 h;
参考文献
You, Jingsong; Verkade, John G.
Journal of Organic Chemistry, 2003 , vol. 68, # 21 p. 8003 - 8007
反应条件
sodium hexamethyldisilazane; Verkade nonionic superbase; palladium diacetate in toluene
T=90°C; 8 h;
参考文献
You, Jingsong; Verkade, John G.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 41 p. 5051 - 5053
反应条件
potassium hexamethylsilazane in tetrahydrofuran
144 h; Heating;
参考文献
Poniatowski, Alexander J.; Floreancig, Paul E.
Synthesis, 2007 , # 15 p. 2291 - 2296
反应条件
indium tribromide in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Chen, Gang; Wang, Zheng; Wu, Jiang; Ding, Kuiling
Organic Letters, 2008 , vol. 10, # 20 p. 4573 - 4576
反应条件
AlCl3, aluminium chloride in dichloromethane
T=20°C; 0.333333 h;
参考文献
Mahoney, Stuart J.; Lou, Tiantong; Bondarenko, Ganna; Fillion, Eric
Organic Letters, 2012 , vol. 14, # 13 p. 3474 - 3477
反应条件
1: (4-methoxy-phenyl)-acetonitrile With lithium diisopropyl amide in cyclohexane
T=-78°C; 2 h;
2: methyl iodide in cyclohexane
T=-78 - 20°C; 15 h;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2006/44732 A2, 2006 ;
Location in patent: Page/Page column 129 ;
WO 2006/044732 A2
反应条件
1: (4-methoxy-phenyl)-acetonitrile With lithium diisopropyl amide in tetrahydrofuran; cyclohexane
T=-78°C; 2 h;
2: methyl iodide in tetrahydrofuran; cyclohexane
T=-78 - 20°C; 15 h;
参考文献
SANOFI-AVENTIS U.S. LLC
Patent: WO2008/39882 A1, 2008 ;
Location in patent: Page/Page column 128 ;
WO 2008/039882 A1
