2-氟-5-三氟甲基苯胺合成路线 （共 13 条）
反应条件
hydrogenchloride; stannous chloride; sodium hydrogencarbonate in methanol
参考文献
KinoPharma, Inc.
Patent: EP2279750 A1, 2011 ;
EP 2279750 A1
反应条件
hydrogenchloride; sodium hydrogencarbonate in methanol; diethyl ether
参考文献
OTSUKA CHEMICAL COMPANY, LIMITED
Patent: EP1243584 A1, 2002 ;
反应条件
1: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C 2: iron; aqueous ammonium chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 78, p. 6034,6037
反应条件
1: KF; DMF; H2O / 160 °C 2: iron; aqueous ammonium chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 78, p. 6034,6037
反应条件
1: PCl5 / Einleiten von Chlor 2: anhydrous HF / 85 °C 3: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C 4: tin; aqueous hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , p. Spl. 113
反应条件
1: anhydrous HF / 85 °C 2: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C 3: tin; aqueous hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , p. Spl. 113
反应条件
(i) aq. HCl, NaNO2, NaBF4, (ii) (pyrolysis); Multistep reaction;
参考文献
Feast,W.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 1547 - 1549
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl acetamide T=165°C; P=4912.9 Torr; 25 h;
参考文献
Perry, Robert J.; Wilson, B. David
Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6351 - 6354
反应条件
1: pyridine / 2 h / 120 °C 2: phosphorus pentasulfide / benzene / 3 h / Heating 3: NaH / toluene / 0.5 h / Heating View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
参考文献
Finger,G.C. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 572 - 573
