(±)-2-乙酰氧基丙酸合成路线 (共 14 条)
反应条件
water; Amberlite IR 120 T=80°C; 16 h; Product distribution / selectivity;
参考文献
Council of Scientific and Industrial Research
Patent: US2007/213558 A1, 2007 ;
Location in patent: Page/Page column 3; 4 ;
反应条件
thionyl chloride T=20°C; Chlorination;
参考文献
Buisson, Didier; Azerad, Robert
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2997 - 3002
参考文献
Chemische Berichte, , vol. 101, # 5 p. 1532 - 1539
Journal of Medicinal Chemistry, , vol. 17, # 10 p. 1057 - 1060
Tetrahedron: Asymmetry, , vol. 6, # 1 p. 43 - 46
反应条件
potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I T=40°C; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst;
参考文献
Chenault, H. Keith; Dahmer, Juergen; Whitesides, George M.
Journal of the American Chemical Society, 1989 , vol. 111, # 16 p. 6354 - 6364
参考文献
Chemische Berichte, , vol. 101, # 5 p. 1532 - 1539
Journal of Medicinal Chemistry, , vol. 17, # 10 p. 1057 - 1060
Tetrahedron: Asymmetry, , vol. 6, # 1 p. 43 - 46
反应条件
(i) H2SO4, (ii) aq. NaOH; Multistep reaction;
参考文献
Shemyakin,M.M. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1966 , p. 2074 - 2078
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1966 , # 12 p. 2143 - 2148
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Studte, Christopher; Breit, Bernhard
Angewandte Chemie - International Edition, 2008 , vol. 47, # 29 p. 5451 - 5455
反应条件
sulfuric acid in dichloromethane; water
参考文献
Kurkin; Belov; Yurovskaya
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 9 p. 1123 - 1128
反应条件
perchloric acid 24 h; Ambient temperature;
参考文献
Hsiao, Chi-Nung; Kolasa, Teodozyj
Tetrahedron Letters, 1992 , vol. 33, # 19 p. 2629 - 2632
反应条件
triethylamine in acetonitrile Ambient temperatureelectrolysis; MechanismProduct distribution;
参考文献
Chemische Berichte, , vol. 116, # 1 p. 375 - 388