1: 98 percent / methanol; H2O; acetonitrile / Ambient temperature
2: 1.) aq. NaNO2, CuCl2 / 1.) RT, 2 h, 2.) H2O, 100 deg C, 1 h
3: acetonitrile / 0.33 h / 75 °C
4: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 16 h / Ambient temperature
5: 74 percent / methanolic ammonia / Ambient temperature
View Scheme
参考文献
Townsend, Leroy B.; Devivar, Rodrigo V.; Turk, Steven R.; Nassiri, M. Reza; Drach, John C.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4098 - 4105
Thompson, Andrew J.; Verheij, Mark H. P.; VanMuijlwijk-Koezen, Jacqueline E.; Lummis, Sarah C. R.; Leurs, Rob; DeEsch, Iwan J. P.
ChemMedChem, 2013 , vol. 8, # 6 p. 946 - 955
