3,5-二甲基-4-硝基苯酚合成路线 （共 21 条）
反应条件
1: 1.) NaBH4, 2.) 3 N HCl / 1.) 10percent Pd-C / 1.) H2O, MeOH, rt, 30 min 2: aq. NaNO2, aq. H2SO4 / 0.33 h / 20 °C View Scheme
参考文献
Bucher, Goetz; Sander, Wolfram
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1346 - 1351
反应条件
2: Raney nickel / 90 °C / 88260.9 Torr / Hydrogenation View Scheme
参考文献
Mijs et al.
Recueil des Travaux Chimiques des Pays-Bas, 1958 , vol. 77, p. 746,747
反应条件
hydrogenchloride; sodium nitrate in diethyl ether; water
T=0 - 20°C;
参考文献
Advanced Medicine, Inc.
Patent: US6337423 B1, 2002 ;
Location in patent: Example 4, 22 ;
US 6337423 B1
反应条件
dihydrogen peroxide; acetic acid; (NH4)6[Mo7O24]*4H2O
T=100°C;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL
Patent: US2009/326059 A1, 2009 ;
Location in patent: Page/Page column 16 ;
US 20090326059 A1
反应条件
in hydrogenchloride; water
参考文献
Theravance, Inc.
Patent: US6462034 B1, 2002 ;
US 6462034 B1
反应条件
hydrogen bromide in acetic acid
3 h; Heating;
参考文献
Bucher, Goetz; Sander, Wolfram
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1346 - 1351
反应条件
Pd(0)EnCat; ammonium formate in N,N-dimethyl-formamide
T=80°C; 0.166667 h; Irradiationmicrowave;
参考文献
Quai, Monica; Repetto, Claudio; Barbaglia, Walter; Cereda, Enzo
Tetrahedron Letters, 2007 , vol. 48, # 7 p. 1241 - 1245
反应条件
in acetic acid; toluene
参考文献
William H. Rorer, Inc.
Patent: US4487779 A1, 1984 ;
反应条件
nitrogen(IV) oxide in chloroform-d1
T=-60°C;
参考文献
Fischer, Alfred; Mathivanan, N.
Tetrahedron Letters, 1988 , vol. 29, # 16 p. 1869 - 1872
反应条件
diethyl ether; nitric acid
参考文献
Adams; Stewart
Journal of the American Chemical Society, 1941 , vol. 63, p. 2859,2861
