4'-硝基苯并-18-冠-6-醚合成路线 （共 8 条）
反应条件
nitric acid in dichloromethane T=20°C; 24 h;
参考文献
Monash University
Patent: WO2003/99762 A1, 2003 ;
Location in patent: Page 27 ;
反应条件
potassium hydroxide; 2,3,11,12-dicyclohexano-1,4,7,10,13,16-hexaoxacyclo-octadecane in tetrahydrofuran 5 h; Heating;
参考文献
Abakumova, N. I.; Kolenko, I. K.; Kodess, M. I.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 1305 - 1307
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 7 p. 1495 - 1498
反应条件
1: 50 percent / 65percent nitric acid / CHCl3 / 0.5 h / 20 - 24 °C 2: 75 percent / 60percent aq. KOH / dicyclohexyl-18-crown-6 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 1305 - 1307
Zhurnal Organicheskoi Khimii, , vol. 18, # 7 p. 1495 - 1498
反应条件
sodium hydroxide; nitric acid 1.) t-BuOH, H2O, reflux, 2.) AcOH, CHCl3, room temperature; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 104, # 7 p. 1960 - 1967
反应条件
1: 90 percent / KOH / H2O / 8 h / Heating 2: KOH / tetrahydrofuran View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 761 - 764
反应条件
potassium hydroxide in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 26, # 22 p. 2705 - 2708
Liebigs Annalen der Chemie, , p. 761 - 764
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Dykes, Graham M.; Smith, David K.
Tetrahedron, 2003 , vol. 59, # 22 p. 3999 - 4009
反应条件
1: H2 / Pd/C / ethanol
2: NaHCO3 / methanol / 0.5 h
3: 32 percent / HNO3 / CHCl3; acetic acid / Ambient temperature
View Scheme
参考文献
Yamashita; Nakamura; Takagi; ueno
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 6 p. 1550 - 1554
