D-(+)-核糖酸-1,4-内酯合成路线 （共 50 条）
反应条件
sulfuric acid 1 h; Ambient temperature; Yield given;
参考文献
Shereshevskii, A. A.; Gyach, N. V.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 2 p. 135 - 139
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 2 p. 196 - 201
参考文献
Hough et al.
Canadian Journal of Chemistry, 1958 , vol. 36, p. 1720,1725
反应条件
potassium hydroxide; platinum T=75°C; P=102971 Torr; Hydrogenation;
参考文献
Jampolsky; Wuest
Journal of the American Chemical Society, 1946 , vol. 68, p. 1777
反应条件
2: zinc chloride 3: toluene; phosphorus (V)-chloride 4: sodium acetate; ethyl acetate / Hydrogenation 5: ethanolic NaOH-solution View Scheme
参考文献
Tishler et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 1329
反应条件
1: 1.) THF, 12 h, reflux, 2.) 7 d 2: 68 percent / 220 °C / 40 Torr View Scheme
参考文献
Camps, P.; Font, J.; Ponsati, O.
Tetrahedron Letters, 1981 , vol. 22, # 15 p. 1471 - 1472
反应条件
Yield given. Multistep reaction;
参考文献
Vekemans, Josef A. J. M.; Franken, Gabriel A. M.; Dapperens, Cornelis W. M.; Godefroi, Erik F.; Chittenden, Gordon J. F.
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 627 - 633
反应条件
1.) THF, reflux; 2.) 220 deg C, 18 Hgmm; Multistep reaction;
参考文献
Camps, P.; Font, J.; Ponsati, O.
Tetrahedron Letters, 1981 , vol. 22, # 15 p. 1471 - 1472
反应条件
1: HCR-W2 H+-Dowex resin / acetone / 4 h / 20 °C 2: 688 mg / DMAP; Et3N / CH2Cl2 / 0 °C View Scheme
参考文献
Batoux, Nathalie E.; Paradisi, Francesca; Engel, Paul C.; Migaud, Marie E.
Tetrahedron, 2004 , vol. 60, # 31 p. 6609 - 6617
反应条件
1: 98 percent / aq. HCl / 7 h / Ambient temperature 2: 1.) NaH 3: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 4: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 5: 84 percent / pyridine / 4 h / Ambient temperature 6: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 7: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature View Scheme
参考文献
Salas-Reyes
Synthetic Communications, 1999 , vol. 29, # 12 p. 2187 - 2199
反应条件
1: 1.) hydrogen bromide, 2.) methanol / 1.) acetic acid, 4 h, rt 2: hydrogen, triethyl amine / Pd/C / ethyl acetate 3: carbon tetrabromide, triphenyl phosphine / acetonitrile 4: hydrogen, triethyl amine / Pd/C / ethyl acetate View Scheme
参考文献
Shin Yih Chen; Joullie
Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5027 - 5030
