D-(+)-核糖酸-1,4-内酯合成路线 （共 50 条）
反应条件
1: With sodium hydrogencarbonate in water T=20°C; 1 h; Large scale; 2: With bromine T=5 - 10°C; 5.5 h; Large scale;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
Location in patent: Page/Page column 93 ;
反应条件
[Rh(H)(PEt3)3]; 4-phenylbut-3-en-2-one in N,N-dimethyl-formamide T=40°C; 1.5 h;
参考文献
Isaac, Isabelle; Stasik, Imane; Beaupere, Daniel; Uzan, Raoul
Tetrahedron Letters, 1995 , vol. 36, # 3 p. 383 - 386
反应条件
water T=80°C; 0.25 h; microwave irradiation;
参考文献
Procopio, Antonio; Gaspari, Marco; Nardi, Monica; Oliverio, Manuela; Tagarelli, Antonio; Sindona, Giovanni
Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8623 - 8627
反应条件
sulfuric acid in water Yield given;
参考文献
Carbohydrate Research, , vol. 220, # 1 p. 117 - 126
反应条件
hydrogenchloride 1.) 60 deg C, 1 h, 2.) 80 deg C, 2 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 16, # 2 p. 135 - 139
Khimiko-Farmatsevticheskii Zhurnal, , vol. 16, # 2 p. 196 - 201
反应条件
1.1: 1 h / 20 °C / |Large scale 1.2: 10 °C / |Large scale 2.1: pyridine / 4 h / -15 - 20 °C / |Inert atmosphere; |Large scale 3.1: potassium hydroxide / water / 3 h / 20 °C / |Large scale 4.1: 4-(N,N-dimethlyamino)pyridine; 1H-imidazole / N,N-dimethyl-formamide / 1 h / |Large scale 4.2: 16 h / 0 - 20 °C / |Inert atmosphere; |Large scale View Scheme
反应条件
sulfuric acid; sodium sulfate Reduktion an einer Quecksilber-Kathode;
参考文献
Beresowskii
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 789,790; engl. Ausg. S. 757, 758
反应条件
1: 98 percent / aq. HCl / 7 h / Ambient temperature 2: 1.) NaH 3: 93 percent / n-Bu3SnH, AIBN / toluene / Heating 4: 96 percent / TFA / H2O; CHCl3 / 10 h / 70 °C 5: 84 percent / pyridine / 4 h / Ambient temperature 6: 1.) PPh3, DEAD, 2.) MeI / 1.) benzene, rt, 24 h, 2.) toluene, rt, 30 min, reflux, 24 h 7: 60 percent / H2 / Pd/C / ethanol / 12 h / Ambient temperature 8: 77 percent / p-TsOH / methanol / 5 h / Ambient temperature View Scheme
参考文献
Hanessian, S.; Murray, P. J.
Tetrahedron, 1987 , vol. 43, # 21 p. 5055 - 5072
反应条件
1: SOBr2 / dimethylformamide / 0 °C 2: I2 / 20 °C View Scheme
参考文献
Ingall, Anthony H.; Moore, Peter R.; Roberts, Stanley M.
Journal of the Chemical Society, Chemical Communications, 1994 , # 1 p. 83 - 84
反应条件
1: 1.) THF, 12 h, reflux, 2.) 7 d 2: 68 percent / 220 °C / 40 Torr 3: 71 percent / pyridine / CH2Cl2 / 14 h / Ambient temperature 4: 63 percent / NaI / acetone / 8 h / Heating 5: 63 percent / CaCO3 / Ni-Ra W-4 / ethanol / 2 h View Scheme
参考文献
Camps, P.; Cardellach, J.; Font, J.; Ortuno, R. M.; Ponsati, O
Tetrahedron, 1982 , vol. 38, # 15 p. 2395 - 2402
