4-氯-1-苯基-1H-吡唑并[3,4-d]嘧啶合成路线 （共 63 条）
反应条件
1: 4-chloro-1-phenyl-1H-pyrazololt;3,4-dgt;pyrimidine With lithium n-butanetelluroate in tetrahydrofuran
T=20°C; 0.166667 h;
2: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.166667 h;
3: methyl vinyl ketone in tetrahydrofuran
T=-78 - 20°C;
参考文献
Sugimoto, Osamu; Sudo, Muneyoshi; Tanji, Ken-Ichi
Tetrahedron, 2001 , vol. 57, # 11 p. 2133 - 2138
反应条件
sodium hydride; 1,3-dimethyl-1H-benzo[d]imidazol-3-ium iodide in N,N-dimethyl-formamide
0.5 h; Ambient temperature;
参考文献
Miyashita; Matsuda; Iijima; Higashino
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1147 - 1152
反应条件
sodium hydride in tetrahydrofuran
1 h; Heating;
参考文献
Miyashita, Akira; Kurachi, Akihito; Matsuoka, Yoshiyuki; Tanabe, Noriko; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1997 , vol. 44, # 1 p. 417 - 426
反应条件
sodium hydride in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1998 , vol. 47, # 1 p. 407 - 414
反应条件
sodium hydride in tetrahydrofuran
1 h; Heating;
参考文献
Miyashita, Akira; Kurachi, Akihito; Matsuoka, Yoshiyuki; Tanabe, Noriko; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1997 , vol. 44, # 1 p. 417 - 426
反应条件
potassium cyanide in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1998 , vol. 47, # 1 p. 407 - 414
反应条件
1: 95 percent / 57percent hydroiodic acid, NaI / butan-2-one / 2 h / Ambient temperature
2: 26 percent / KCN / dimethylformamide / 1 h / 80 °C
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
反应条件
sodium hydride; 2-methylpyridolt;1,2-cgt;imidazolium iodide in tetrahydrofuran
1 h; Heating;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Kobayashi, Motoi; Kuriyama, Naomi; Higashino, Takeo
Heterocycles, 1996 , vol. 43, # 3 p. 509 - 512
反应条件
sodium hydride; [mmim][I] in tetrahydrofuran
0.5 h; Heating;
参考文献
Miyashita; Matsuda; Suzuki; Iwamoto; Higashino
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 10 p. 2017 - 2022
反应条件
pyridine
5 h; Heating;
参考文献
Ghorab; Ismail, Zeinab H.; Abdel-Gawad, Soad M.; Aziem, Anhar Abdel
Heteroatom Chemistry, 2004 , vol. 15, # 1 p. 57 - 62
