4-氯-1-苯基-1H-吡唑并[3,4-d]嘧啶合成路线 （共 63 条）
反应条件
ethanol; ammonia T=160°C;
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242
反应条件
trichlorophosphate in 1,2-dichloro-ethane
T=90°C; 12 h;
参考文献
Chern, Jyh-Haur; Shia, Kak-Shan; Hsu, Tsu-An; Tai, Chia-Liang; Lee, Chung-Chi; Lee, Yen-Chun; Chang, Chih-Shiang; Tseng, Sung-Nien; Shih, Shin-Ru
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2519 - 2525
反应条件
in acetonitrile
T=200°C; 0.0166667 h; Microwave irradiation;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
in acetonitrile
T=200°C; 0.333333 h; Microwave irradiation;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
sodium hydroxide in dichloromethane; water
6 h; Inert atmosphere;
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
triethylamine in tetrahydrofuran
T=65°C; 1 h;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
1: triethylamine / chloroform / 1 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
2: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: triethylamine / chloroform / 1 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: H2O / 24 h / Heating
2: POCl3; DMF / 4 h / Heating
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
