5-氨基-1-苯基吡唑-4-腈合成路线 （共 44 条）
反应条件
sodium methylate in 1,4-dioxane
18 h; Reflux;
参考文献
Xu, Lifeng
Patent: US2012/178915 A1, 2012 ;
Location in patent: Page/Page column 12; 25 ;
反应条件
1: 93 percent / acetic acid / 0.5 h / Heating
2: 80 percent / LiAlH4 / tetrahydrofuran / 18 h / Ambient temperature
3: 65 percent / acetic acid / 1 h / Ambient temperature
View Scheme
参考文献
Massa; Stefancich; Artico; Corelli
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 6 p. 1877 - 1880
反应条件
in acetic acid
0.5 h; Heating;
参考文献
Massa; Stefancich; Artico; Corelli
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 6 p. 1877 - 1880
反应条件
1: sulfuric acid / 1 h / 20 °C
2: sodium ethanolate / ethanol / 0.01 h / 15001.5 Torr / |Reflux; |Microwave irradiation
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
参考文献
Karoui, Amine; Allouche, Fatma; Deghrigue, Monia; Agrebi, Asma; Bouraoui, Abderrahman; Chabchoub, Fakher
Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1591 - 1598
反应条件
1: With diisobutylaluminium hydride in hexane; toluene
T=-78 - -70°C; 0.333333 h;
2: With hydrogenchloride; water
T=0 - 26°C;
参考文献
VALEANT RESEARCH AND DEVELOPMENT
Patent: WO2006/33995 A2, 2006 ;
Location in patent: Page/Page column 31-32 ;
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 191,195
反应条件
1: dihydrogen peroxide; ammonium hydroxide / 20 °C
2: 200 °C
3: phosphorus pentachloride; trichlorophosphate / |Reflux
4: potassium hydroxide / 60 °C
View Scheme
参考文献
Meng, Fei; Huang, Manna; Zhu, Xinhai; Wan, Yiqian; Hou, Jing; Shao, Yong-Xian; Cai, Yonghong; Li, Zhe; Xu, Jie; Liu, Peiqing; Luo, Hai-Bin; Ke, Hengming; Wu, Pei-Ying
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8549 - 8558,10
反应条件
pyridine
7 h; Reflux;
参考文献
Allouche, Fatma; Chabchoub, Fahker; Salem, Mansour; Kirsch, Gilbert
Synthetic Communications, 2011 , vol. 41, # 10 p. 1500 - 1507
反应条件
1: sulfuric acid / 1 h / 20 °C
2: sodium ethanolate / ethanol / 0.01 h / 15001.5 Torr / |Reflux; |Microwave irradiation
3: trichlorophosphate / 0.08 h / 120 °C / 22502.3 Torr / |Microwave irradiation
4: toluene / 20 °C
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
