5-氨基-1-苯基吡唑-4-腈合成路线 （共 44 条）
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water
T=20°C; 20 h;
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water
T=20°C; 20 h;
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
tert.-butylnitrite in tetrahydrofuran
2 h; Reflux;
参考文献
Dos Santos, Mauricio S.; Bernardino, Alice M. R.; Pinheiro, Luiz C. S.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 6 p. 1425 - 1428
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water
T=20°C; 6 h; Irradiation;
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
hydrogenchloride; sodium nitrite in ethanol; water
T=20°C; 20 h;
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
ammonia in methanol
T=200°C; 45 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/54294 A1, 2007 ;
Location in patent: Page/Page column 32-33 ;
WO 2007/054294 A1
反应条件
1: acetic acid / 24 h / |Reflux
2: acetic acid; ammonia / ethanol / 6 h / |Reflux
View Scheme
参考文献
Karoui, Amine; Allouche, Fatma; Deghrigue, Monia; Agrebi, Asma; Bouraoui, Abderrahman; Chabchoub, Fakher
Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1591 - 1598
反应条件
1: sulfuric acid / 1 h / 20 °C
2: sodium ethanolate / ethanol / 0.01 h / 15001.5 Torr / |Reflux; |Microwave irradiation
3: trichlorophosphate / 0.08 h / 120 °C / 22502.3 Torr / |Microwave irradiation
4: toluene / 20 °C
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
反应条件
1: H2O / 24 h / Heating
2: POCl3; DMF / 4 h / Heating
3: hydrazine hydrate / ethanol / 24 h / 45 °C
View Scheme
参考文献
Abd El Razik, Heba A.; Abdel Wahab, Abeer E.
Archiv der Pharmazie, 2011 , vol. 344, # 3 p. 184 - 196
反应条件
1: sulfuric acid / 1 h / 20 °C
2: sodium ethanolate / ethanol / 0.01 h / 15001.5 Torr / |Reflux; |Microwave irradiation
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
