2-巯基-5-氯苯并噻唑合成路线 （共 17 条）
参考文献
Hoechst A.G.
Patent: US4431813 A1, 1984 ;
反应条件
in N,N-dimethyl-formamide T=120°C; 0.2 h; microwave irradiation;
参考文献
Huang, Wei; Tan, Ying; Ding, Ming-Wu; Yang, Guang-Fu
Synthetic Communications, 2007 , vol. 37, # 3 p. 369 - 376
反应条件
potassium hydroxide in ethanol; water Reflux;
参考文献
Stella, Alessandro; Segers, Kenneth; De Jonghe, Steven; Vanderhoydonck, Bart; Rozenski, Jef; Anne, Jozef; Herdewijn, Piet
Chemistry and Biodiversity, 2011 , vol. 8, # 2 p. 253 - 265
反应条件
sodium hydroxide T=20°C; 1 h;
参考文献
COMPOUND HANDLING B.V.; STICHTING KATHOLIEKE UNIVERSITEIT; HOOIJ, VAN, Onno; SCHALKEN, Jacobus Antonius; VIËTOR, Hendrik Engelbertus; PIET, Dennis Patrick; MAAS, Petrus Emmanuel Marie; TIJHUIS, Johann Heinrich; DEERENBERG, Sirik; SPRENKELS, Nanda Elisabeth; TANG, Siu Ha
Patent: WO2013/131931 A1, 2013 ;
Location in patent: Page/Page column 29; 30 ;
反应条件
1: sodium hydroxide / 1 h / 20 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C 3: hydrazine hydrate / ethanol; water / 3 h / Reflux View Scheme
参考文献
COMPOUND HANDLING B.V.; STICHTING KATHOLIEKE UNIVERSITEIT; HOOIJ, VAN, Onno; SCHALKEN, Jacobus Antonius; VIËTOR, Hendrik Engelbertus; PIET, Dennis Patrick; MAAS, Petrus Emmanuel Marie; TIJHUIS, Johann Heinrich; DEERENBERG, Sirik; SPRENKELS, Nanda Elisabeth; TANG, Siu Ha
Patent: WO2013/131931 A1, 2013 ;
反应条件
iron in acetic acid Heating;
参考文献
Vanderbilt Co.
Patent: US2509453 , 1947 ;
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Vanderbilt Co.
Patent: US2509454 , 1947 ;
反应条件
hydrogenchloride; sodium hydroxide; sodium hypochlorite 1.)80-90 deg C, 1 h, 2.)95-100 deg C, 1.5 h;
参考文献
D'Amico, John J.; Bollinger, Frederick G.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1183 - 1190
反应条件
sulfuryl dichloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate T=0°C; 1.25 h;
参考文献
Amgen Inc.
Patent: US2005/250820 A1, 2005 ;
Location in patent: Page/Page column 71 ;
US 20050250820 A1
反应条件
in sulfuryl dichloride; ethanol
参考文献
Adir et Compagnie
Patent: US5550143 A1, 1996 ;
反应条件
sodium hydroxide
24 h;
参考文献
Brown; Grigg; Iwai; et al.
Australian Journal of Chemistry, 1979 , vol. 32, # 12 p. 2713 - 2726
