N-Boc-L-正缬氨酸合成路线 （共 11 条）
反应条件
1: 82 percent / CDI, DIEA / tetrahydrofuran; dimethylformamide / Ambient temperature
2: 90 percent / LiAlH4 / diethyl ether / 0.5 h / 0 - 5 °C
3: 1.) aq. NaHSO3 / 1.) MeOH, 5 deg C, overnight, 2.) MeOH, H2O, AcOEt, RT, 5 h
4: conc. aq. HCl, anisole / dioxane / Heating
View Scheme
参考文献
Harbeson, Scott L.; Abelleira, Susan M.; Akiyama, Alan; Barrett, Robert; Carroll, Renee M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2918 - 2929
