5-氨基-2-乙酰氨基苯甲醚合成路线 （共 9 条）
反应条件
sulfuric acid; sodium nitrite Erhitzen der Reaktionsloesung mit Kupfer(I)-bromid;
参考文献
Hanford; Adams
Journal of the American Chemical Society, 1935 , vol. 57, p. 1592,1594
反应条件
1: aqueous sulfuric acid; sodium nitrite / Erhitzen der Reaktionsloesung mit Kupfer(I)-bromid 2: Diazotization View Scheme
参考文献
Hanford; Adams
Journal of the American Chemical Society, 1935 , vol. 57, p. 1592,1594
反应条件
1: pyridine / CH2Cl2 / 25 °C 2: 82 percent / conc. HCl / ethanol; H2O / reflux, 5 h; 25 deg C, overnight View Scheme
参考文献
Brennan; Colbry; Leeds; Leja; Priebe; Reily; Showalter; Uhlendorf; Atwell; Denny
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1469 - 1476
参考文献
Hanford; Adams
Journal of the American Chemical Society, 1935 , vol. 57, p. 1592,1594
Full Text Show Details
I.G.Farbenind.
Patent: DE552267 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1222
反应条件
1: 97 percent / acetic acid / 1 h / 80 °C
2: H2 / Raney nickel / methanol / 22.5 h / 2585.7 Torr
View Scheme
参考文献
Brennan; Colbry; Leeds; Leja; Priebe; Reily; Showalter; Uhlendorf; Atwell; Denny
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1469 - 1476
反应条件
1: aqueous NaOH-solution
2: iron; aqueous acetic acid
View Scheme
参考文献
I.G.Farbenind.
Patent: DE552267 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1222
反应条件
sodium tetrahydroborate; sulfuric acid in tetrahydrofuran; water
T=0°C;
参考文献
Xue, Lin; Li, Guoping; Liu, Qing; Wang, Huanhuan; Liu, Chun; Ding, Xunlei; He, Shenggui; Jiang, Hua
Inorganic Chemistry, 2011 , vol. 50, # 8 p. 3680 - 3690
反应条件
pyridine in chloroform
T=0 - 25°C; 2 h;
参考文献
Sundberg; Baxter; Pitts; Ahmed-Schofield; Nishiguchi
Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5097 - 5107
反应条件
1: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) H2O, acetone, 5 deg C, 15 min, 2.) H2O, acetone, 5 -> 35 deg C
2: 57.5 percent / AcONa / 2-methoxy-ethanol / 16 h / 100 °C
3: 64.7 percent / 6N HCl / ethanol / 20 h
View Scheme
参考文献
Sohda; Mizuno; Hirata; Maki; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 560 - 569
