4-(4-氯苄基)-1-(2H)-酞嗪酮合成路线 （共 8 条）
反应条件
1: With hydrazine in ethanol T=85°C; 15 h; 2: With acetone in ethanol T=2°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122156 A1, 2007 ;
Location in patent: Page/Page column 114-115 ;
WO 2007/122156 A1
参考文献
Derita, Marcos; Del Olmo, Esther; Barboza, Bianca; Garcia-Cadenas, Ana Esther; Lopez-Perez, Jose Luis; Andujar, Sebastian; Enriz, Daniel; Zacchino, Susana; Feliciano, Arturo San
Molecules, 2013 , vol. 18, # 3 p. 3479 - 3501
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=180°C; 0.333333 h; Microwave irradiation;
参考文献
US2011/124642 A1, ;
Page/Page column 41 ;
反应条件
hydrazine hydrate; sodium hydroxide T=90°C; 0.5 h; Microwave irradiation;
参考文献
Havaldar, Freddy H.; Dabholkar, Bhushan V.; Mule, Ganesh B.
Synthetic Communications, 2013 , vol. 43, # 8 p. 1127 - 1137
反应条件
sodium hydroxide; monohydrazine sulfate 2 h; Heating;
参考文献
Scheffler; Engel; Kutscher; Sheldrick; Bell
Archiv der Pharmazie, 1988 , vol. 321, # 4 p. 205 - 208
反应条件
1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating 3: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 321, # 4 p. 205 - 208
反应条件
1: sodium acetate / acetonitrile / 0.33 h / 85 °C / |Microwave irradiation 2: sodium hydroxide; hydrazine hydrate / 0.5 h / 90 °C / |Microwave irradiation View Scheme
参考文献
Synthetic Communications, , vol. 43, # 8 p. 1127 - 1137
反应条件
sodium hydroxide T=70°C; 1 h; Yield given;
参考文献
Scheffler; Engel; Kutscher; Sheldrick; Bell
Archiv der Pharmazie, 1988 , vol. 321, # 4 p. 205 - 208
