1-(1-苯基乙基)哌嗪合成路线 （共 14 条）
反应条件
hydrogen; triethylamine; palladium dihydroxide in ethanol T=40°C; P=1500.15 - 3000.3 Torr; 7 h;
参考文献
Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael; Heinrich, Timo; Boettcher, Henning; Beller, Matthias
Chemistry - A European Journal, 2004 , vol. 10, # 3 p. 746 - 757
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6172085 B2, 2001 ;
US 6172085 B1
反应条件
in toluene T=85°C; 2 h;
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A.
Australian Journal of Chemistry, 2003 , vol. 56, # 9 p. 875 - 886
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 20 °C 1.2: 94 percent / tetrahydrofuran; hexane / 24 h / 120 °C 2.1: 95 percent / H2; Et3N / Pd(OH)2/C / ethanol / 7 h / 40 °C / 1500.15 - 3000.3 Torr View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 3 p. 746 - 757
参考文献
GB840358 , ;
Journal of the American Chemical Society, , vol. 66, p. 263,265
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; Yield given;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 112, # 2 p. 143 - 150
反应条件
1: K2CO3 / ethanol / Heating 2: TFA / CH2Cl2 / Ambient temperature View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 10 p. 1731 - 1743
反应条件
trifluoroacetic acid in dichloromethane Ambient temperature;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 10 p. 1731 - 1743
反应条件
sodium hydroxide in methanol Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 339 - 347
反应条件
hydrogenchloride Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2838 - 2843
