(E)-4-((羟基亚氨基)甲基)苯甲酸甲酯合成路线 （共 14 条）
反应条件
1: NEt3 / CH2Cl2 / 1 h / 0 °C
2: Pd(PPh3)4 / dimethylformamide / 30 h / 80 °C
3: formic acid / Raney-nickel / 10 h / 110 °C
4: H2NOH*HCl; aq. Na2CO3 / 2 h / 20 °C
View Scheme
参考文献
Epple, Robert; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing; Cow, Christopher; Wityak, John; Karanewsky, Don; Bursulaya, Badry; Kreusch, Andreas; Tuntland, Tove; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5488 - 5492
反应条件
1: 100 percent / H2SO4 / 8 h / Heating
2: NEt3 / CH2Cl2 / 1 h / 0 °C
3: Pd(PPh3)4 / dimethylformamide / 30 h / 80 °C
4: formic acid / Raney-nickel / 10 h / 110 °C
5: H2NOH*HCl; aq. Na2CO3 / 2 h / 20 °C
View Scheme
参考文献
Epple, Robert; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing; Cow, Christopher; Wityak, John; Karanewsky, Don; Bursulaya, Badry; Kreusch, Andreas; Tuntland, Tove; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5488 - 5492
反应条件
1: formic acid / Raney-nickel / 10 h / 110 °C
2: H2NOH*HCl; aq. Na2CO3 / 2 h / 20 °C
View Scheme
参考文献
Epple, Robert; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing; Cow, Christopher; Wityak, John; Karanewsky, Don; Bursulaya, Badry; Kreusch, Andreas; Tuntland, Tove; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5488 - 5492
反应条件
1: With water; hydrogen
T=45°C; P=7355.72 Torr; 4 h;
2: With hydrogenchloride in water
pH=4.5;
参考文献
NAF Co., Ltd.; SK Petrochemical Co., Ltd.
Patent: EP2524909 A2, 2012 ;
Location in patent: Page/Page column 5 ;
