8-甲氧基-3,4-二氢-1H-2-萘酮合成路线 （共 32 条）
反应条件
1: With sodium in ethanol Heating / reflux; 2: With hydrogenchloride in ethanol; water T=10°C; pH=6; 1 h; Heating / reflux;
参考文献
WYETH
Patent: WO2005/12291 A1, 2005 ;
Location in patent: Page/Page column 76 ;
WO 2005/012291 A1
参考文献
Journal of the Chemical Society, , p. 409,416
反应条件
potassium carbonate; dimethyl sulfate in water; acetone
参考文献
Eli Lilly and Company
Patent: US5026707 A1, 1991 ;
US 5026707 A
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethyl acetate
参考文献
Tetrahedron Asymmetry, , vol. 13, # 3 p. 253 - 259
反应条件
sodium hydroxide; NaCNBH3; p-TsOH in methanol; benzene
参考文献
US5690906 A1, ;
US 5690906 A
反应条件
hydrogenchloride; sodium hydrogen sulphate; sodium in ethanol; water
参考文献
Zeneca Limited
Patent: US5807897 A1, 1998 ;
反应条件
acetic acid T=100°C; 3 h;
参考文献
Lee; Frescas; Nichols
Synthetic Communications, 1995 , vol. 25, # 18 p. 2775 - 2780
反应条件
[rhodium(I)(carbonyl)2(acetylacetonate)]; trifluoroacetic acid in dichloromethane 0.416667 h; Heating;
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
反应条件
1: 96 percent / H2 / 10percent Pd/C / aq. ethanol / 2660 Torr 2: 94 percent / SOCl2 / benzene / 3 h / Heating 3: 98 percent / diethyl ether / Ambient temperature 4: 19 percent / <Rh(CH3COO)2>2, CF3COOH / CH2Cl2 / 0.42 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 20 p. 2891 - 2898
反应条件
1: 93 percent / piperidine, pyridine / 4 h / 85 - 110 °C 2: 96 percent / H2 / 10percent Pd/C / aq. ethanol / 2660 Torr 3: 94 percent / SOCl2 / benzene / 3 h / Heating 4: 98 percent / diethyl ether / Ambient temperature 5: 19 percent / <Rh(CH3COO)2>2, CF3COOH / CH2Cl2 / 0.42 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 20 p. 2891 - 2898
