4-(4-甲氧基苯基)环己酮合成路线 （共 16 条）
反应条件
potassium carbonate in water; acetone
参考文献
Chen, Li; Cheung, Adrian Wai-Hing; Chu, Xin-Jie; Danho, Waleed; Swistok, Joseph; Wang, Yao; Yagaloff, Keith Alan
Patent: US2002/143141 A1, 2002 ;
US 20020143141 A1
反应条件
toluene-4-sulfonic acid in acetone T=60°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4910 - 4914
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=20°C; 3 h; atmospheric pressure;
参考文献
Friese, Anke; Hell-Momeni, Katja; Zuendorf, Ilse; Winckler, Thomas; Dingermann, Theodor; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1535 - 1542
反应条件
1: TsOH / benzene / Heating 2: H2 / Pd/C / ethyl acetate / 3 h 3: TsOH / acetone / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4910 - 4914
反应条件
1: H2 / Pd/C / ethyl acetate / 3 h 2: TsOH / acetone / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4910 - 4914
反应条件
1.1: Mg / tetrahydrofuran 1.2: 77.2 percent / tetrahydrofuran / 24 h / Heating 2.1: 41 percent / trifluoroacetic acid / 0.5 h / 20 °C 3.1: 41 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1535 - 1542
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 20 °C / 2585.81 Torr 3: hydrogenchloride / acetone / 4 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5577 - 5582
反应条件
Al tri-t-BuO-; acetone
参考文献
Journal of the American Chemical Society, , vol. 74, p. 5631
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 20 °C / 2585.81 Torr 3: hydrogenchloride / acetone / 4 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5577 - 5582
反应条件
(i) CF3CO2H, (ii) H2, Pd-C; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 15, # 12 p. 1239 - 1243
