反应条件
1: 4-amino-2-trifluoromethylbenzaldehyde With hydrogenchloride in water; ethyl acetate; toluene
T=20 - 25°C; 0.0833333 h; Large scale;
2: N-ethyl-piperazine With pyridinium p-toluenesulfonate in ethyl acetate
T=76 - 78°C; Large scale;
3: With sodium tris(acetoxy)borohydride in ethyl acetate
Large scale;
参考文献
Shieh, Wen-Chung; Mckenna, Joe; Sclafani, Joseph A.; Xue, Song; Girgis, Michael; Vivelo, James; Radetich, Branko; Prasad, Kapa
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1146 - 1155