2-甲基-4-甲氧基苯酚合成路线 （共 30 条）
反应条件
1.1: NaH / dimethylformamide / 0.5 h / 20 °C
1.2: 71 percent / dimethylformamide / 0 - 20 °C
2.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 - 0 °C
2.2: 94 percent / hexane; diethyl ether / -78 - 20 °C
3.1: 89 percent / aq. HCl / methanol / 20 °C
View Scheme
参考文献
Clark, Richard F.; Zhang, Tianyuan; Wang, Xiaojun; Wang, Rongqi; Zhang, Xiaolin; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.; Gu, Yu Gui
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1961 - 1965
反应条件
1.1: 74 percent / bromine / CHCl3 / 0 - 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: 71 percent / dimethylformamide / 0 - 20 °C
3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 - 0 °C
3.2: 94 percent / hexane; diethyl ether / -78 - 20 °C
4.1: 89 percent / aq. HCl / methanol / 20 °C
View Scheme
参考文献
Clark, Richard F.; Zhang, Tianyuan; Wang, Xiaojun; Wang, Rongqi; Zhang, Xiaolin; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.; Gu, Yu Gui
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1961 - 1965
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 - 0 °C
1.2: 94 percent / hexane; diethyl ether / -78 - 20 °C
2.1: 89 percent / aq. HCl / methanol / 20 °C
View Scheme
参考文献
Clark, Richard F.; Zhang, Tianyuan; Wang, Xiaojun; Wang, Rongqi; Zhang, Xiaolin; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.; Gu, Yu Gui
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1961 - 1965
反应条件
sodium hydroxide in methanol
参考文献
Hecker,E.; Meyer,E.
Chemische Berichte, 1964 , vol. 97, p. 1926 - 1939
反应条件
hydrogenchloride; acetic acid
T=60 - 70°C;
参考文献
Baker; Brown
Journal of the Chemical Society, 1948 , p. 2303,2306
反应条件
vanadium oxide compounds in cyclohexane
T=340°C; 4 h; other catalysts, other time, other temperature; Product distributionKinetics;
参考文献
Korenskii, V. I.; Skoboleva, V. D.; Kolenko, I. P.; Volkov, V. L.; Gus'kova, L. M.
J. Appl. Chem. USSR (Engl. Transl.), 1981 , vol. <2> 54, # 10 p. 2510 - 2514,2215 - 2218
反应条件
sodium in tetrahydrofuran; ammonia
T=3.5°C; Heating; Product distribution;
参考文献
Bunnett, Joseph F.; Jenvey, Judy
Journal of Organic Chemistry, 1996 , vol. 61, # 23 p. 8069 - 8073
参考文献
Bamberger
Justus Liebigs Annalen der Chemie, 1912 , vol. 390, p. 175
Chemische Berichte, 1907 , vol. 40, p. 1903
反应条件
1: concentrated sulfuric acid / 25 °C / durch wochenlange Einw.
2: Diazotization.man zersetzt die Diazo-Loesung durch Wasser
View Scheme
参考文献
Bamberger
Justus Liebigs Annalen der Chemie, 1912 , vol. 390, p. 175
Chemische Berichte, 1907 , vol. 40, p. 1903
反应条件
formic acid
1 h; Heating; Product distribution;
参考文献
Watanabe; Date; Kawanishi; Hori; Furukawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2637 - 2643
