1,3,3-三甲基环己烷甲胺合成路线 （共 4 条）
反应条件
1.1: 99 percent / NaBH4 / methanol / 0.5 h / 0 - 20 °C
2.1: Et3N / CH2Cl2 / 1 h / 0 - 20 °C
3.1: 2,6-lutidine / 1.5 h / 200 °C
3.2: H2 / Pd/C / methanol
4.1: LiAlH4*AlCl3 / diethyl ether
View Scheme
参考文献
Dischino, Douglas D.; Cianci, Christopher; Krystal, Mark; Meanwell, Nicholas A.; Morimoto, Hiromi; Pearce, Bradley C.; Williams, Philip; Yu, Kuo-Long
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 965 - 974
反应条件
1.1: ammonium chloride / N,N-dimethyl-formamide; water / 20 h / 80 °C
2.1: hydrogenchloride; zinc / diethyl ether / 2 h / -20 - 0 °C
2.2: Reflux
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; CHEN, Li; LIN, Xianfeng; QIU, Zongxing; TANG, Guozhi; WANG, Lisha; WU, Jim Zhen; YANG, Wengang
Patent: WO2011/95576 A1, 2011 ;
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether
Reduction;
参考文献
Dischino, Douglas D.; Cianci, Christopher; Krystal, Mark; Meanwell, Nicholas A.; Morimoto, Hiromi; Pearce, Bradley C.; Williams, Philip; Yu, Kuo-Long
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 965 - 974
反应条件
1.1: 2,6-lutidine / 1.5 h / 200 °C
1.2: H2 / Pd/C / methanol
2.1: LiAlH4*AlCl3 / diethyl ether
View Scheme
参考文献
Dischino, Douglas D.; Cianci, Christopher; Krystal, Mark; Meanwell, Nicholas A.; Morimoto, Hiromi; Pearce, Bradley C.; Williams, Philip; Yu, Kuo-Long
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 965 - 974
