4-氨基-6-氯嘧啶合成路线

BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 152 ;
WO 2011/053292 A1

67-56-1甲醇+

5305-59-94-氨基-6-氯嘧啶+

201230-82-2

77817-12-0

参考文献

F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/35039 A1, 2012 ;
Location in patent: Page/Page column 113 ;
WO 2012/035039 A1

110-91-8吗啉+

5305-59-94-氨基-6-氯嘧啶

96225-80-8

参考文献

Riker Laboratories, Inc.
Patent: US4503050 A1, 1985 ;

123-75-1四氢吡咯+

5305-59-94-氨基-6-氯嘧啶

76620-99-0

参考文献

SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
Location in patent: Page/Page column 175 ;

5305-59-94-氨基-6-氯嘧啶+

74-89-5甲胺

66131-69-9

参考文献

Whitehead; Traverso
Journal of the American Chemical Society, 1958 , vol. 80, p. 2182,2184