4,6-二氯-5-嘧啶甲醛合成路线 （共 55 条）
反应条件
1: N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
2: 1,4-dioxane / 0.33 h / 200 °C / |Sealed tube
View Scheme
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane
Condensation;
2: With chloranil
Dehydrogenation;
参考文献
Motmans, Filip; Ceulemans, Erik; Smeets, Stefan; Dehaen, Wim
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7545 - 7548
反应条件
sodium methylate in methanol
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1211246 A1, 2002 ;
参考文献
Motmans, Filip; Ceulemans, Erik; Smeets, Stefan; Dehaen, Wim
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7545 - 7548
反应条件
1: 4,6-dichloro-pyrimidine-5-carboxaldehyde With triethylamine in tetrahydrofuran
T=0°C; 0.166667 h; Inert atmosphere;
2: 2-hydrazinoethanol in tetrahydrofuran
T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
1: 4,6-dichloro-pyrimidine-5-carboxaldehyde With triethylamine in tetrahydrofuran
T=0°C; 0.166667 h; Inert atmosphere;
2: (2-hydroxyethyl)hydrazine hydrochloride in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
Mg(2+)*CO4(2-); N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=200°C; 0.0833333 h; Microwave irradiation;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
triethylamine in tetrahydrofuran
T=65°C; 1 h;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
triethylamine in tetrahydrofuran
T=65°C; 1 h; Inert atmosphere; Reagent/catalyst;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
1: triethylamine / tetrahydrofuran / 1 h / 65 °C / |Inert atmosphere
2: acetonitrile / 0.33 h / 200 °C / |Microwave irradiation
View Scheme
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
