4,6-二氯-5-嘧啶甲醛合成路线

1193-24-44,6-二羟基嘧啶→5305-40-84,6-二氯-5-嘧啶甲醛

参考文献

JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/135719 A1, 2006 ;
Location in patent: Page/Page column 46-47 ;
WO 2006/135719 A1

68-12-2N,N-二甲基甲酰胺+1193-24-44,6-二羟基嘧啶→5305-40-84,6-二氯-5-嘧啶甲醛

参考文献

Gaul, Michael David; Xu, Guozhang; Baumann, Christian Andrew
Patent: US2006/281764 A1, 2006 ;
Location in patent: Page/Page column 25 ;
US 20060281764 A1

14256-99-64,6-二羟基-5-醛基嘧啶→5305-40-84,6-二氯-5-嘧啶甲醛

参考文献

Wittman, Mark D.; Balasubramanian, Neelakantan; Velaparthi, Upender; Zimmermann, Kurt; Saulnier, Mark G.; Liu, Peiying; Sang, Xiaopeng; Frennesson, David B.; Stoffan, Karen M.; Tarrant, James G.; Marinier, Anne; Roy, Stephan
Patent: US2004/44203 A1, 2004 ;
Location in patent: Page 30 ;
US 20040044203 A1

1193-21-14,6-二氯嘧啶+68-12-2N,N-二甲基甲酰胺→5305-40-84,6-二氯-5-嘧啶甲醛

参考文献

BAYER HEALTHCARE AG
Patent: WO2004/43926 A1, 2004 ;
Location in patent: Page 140 ;
WO 2004/043926 A1

59-88-1盐酸苯肼+5305-40-84,6-二氯-5-嘧啶甲醛→

参考文献

Organic Letters, , vol. 15, # 8 p. 1882 - 1885

100-63-0苯肼+5305-40-84,6-二氯-5-嘧啶甲醛→

参考文献

Tetrahedron Letters, , vol. 49, # 52 p. 7395 - 7397

110-89-4哌啶+5305-40-84,6-二氯-5-嘧啶甲醛→54503-93-44-氯-6-哌啶-5-嘧啶甲醛

参考文献

Ryabova; Evstratova; Makarov; Tafeenko; Granik
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 10 p. 1352 - 1358

5305-40-84,6-二氯-5-嘧啶甲醛+74-89-5甲胺→14160-94-2

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 12 p. 3495 - 3499

637-60-5对甲苯肼盐酸盐+5305-40-84,6-二氯-5-嘧啶甲醛→23000-47-74-氯-1-(对甲苯)-1H-吡唑并[3,4-d]嘧啶

参考文献

Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806

5305-40-84,6-二氯-5-嘧啶甲醛→5399-92-84-氯-1H-吡唑并[3,4-d]嘧啶

参考文献

Sunesis Pharmaceuticals, Inc
Patent: US2009/5359 A1, 2009 ;
Location in patent: Page/Page column 18 ;
US 20090005359 A1