5-甲酰基-2-甲基吡啶合成路线 （共 22 条）
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
4: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
5: sodium methoxide / methanol / 18 h / Heating
6: 67 percent / 2.) ethanolic hydrogen chloride / ethanol / 24 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
hydroxylamine in methanol; water
T=40°C; 2 h;
参考文献
Wu, Gang; Mikkilineni, Amarendra B.; Sher, Philip M.; Murugesan, Natesan; Gu, Zhengxiang
Patent: US2006/287341 A1, 2006 ;
Location in patent: Page/Page column 46 ;
US 20060287341 A1
