5-甲酰基-2-甲基吡啶合成路线 （共 22 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-60°C; 1.5 h;
参考文献
Wu, Gang; Mikkilineni, Amarendra B.; Sher, Philip M.; Murugesan, Natesan; Gu, Zhengxiang
Patent: US2006/287341 A1, 2006 ;
Location in patent: Page/Page column 46 ;
US 20060287341 A1
反应条件
1: 5-Bromo-2-methyl-pyridine With n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; hexane T=-10°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h;
参考文献
Kii, Satoshi; Akao, Atsushi; Iida, Takehiko; Mase, Toshiaki; Yasuda, Nobuyoshi
Tetrahedron Letters, 2006 , vol. 47, # 12 p. 1877 - 1879
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane T=-10°C; 0.166667 h; Inert atmosphere; 2: With water in hexane; dichloromethane T=20°C; 1 h;
参考文献
US2011/237584 A1, ;
Page/Page column 134 ;
US 20110237584 A1
反应条件
sodium periodate; osmium(VIII) oxide in ethylene glycol dimethyl ether; water
参考文献
US4559344 A1, ;
US 4559344 A
反应条件
1: i-PrMgCl / toluene; tetrahydrofuran / 0.5 h / -10 °C 2: DIBAL-H / toluene / 0.5 h / -20 - -5 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
反应条件
diisobutylaluminium hydride in toluene T=-20 - -5°C; 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
参考文献
TRUSTEES OF TUFTS COLLEGE
Patent: WO2008/16968 A2, 2008 ;
Location in patent: Page/Page column 70 ;
反应条件
1: 89 percent / sodium bis(2-methoxyethoxy)aluminum hydride / diethyl ether / Heating 2: 57 percent / Pb(OAc)4 / toluene / 2.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 3 p. 583 - 593
反应条件
hydrogenchloride; water; 3-nitro-benzaldehyde
参考文献
Gazzetta Chimica Italiana, , vol. 86, p. 386,388
反应条件
1: Raney nickel; ethanol / Hydrogenation.unter Zusatz einer wss. Loesung von Semicarbazid-hydrochlorid und Natriumacetat 2: 3-nitro-benzaldehyde; hydrochloric acid; water View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 86, p. 386,388
