2,8-DIMETHYL-6H,12H-5,11-METHANODIBENZO[B,F][1,5]DIAZOCINE合成路线 （共 6 条）
反应条件
resolving agent: trans-cellulose tris(4-phenylazophenylcarbamate) ( CPAPC ) adsorbed on silica gel; optical resolution degree examined by HPLC on cis/trans-CPAPC;
参考文献
RUDJER BOSKOVIC INSTITUTE
Patent: WO2009/109792 A1, 2009 ;
Location in patent: Page/Page column 16; Figure 5 ;
反应条件
1: 1,2-dichloro-ethane / 120 h / 45 - 50 °C / |Resolution of racemate 2: sodium carbonate / dichloromethane; water View Scheme
参考文献
Jameson, Donald L.; Field, Thomas; Schmidt, Monica R.; Destefano, Alyson K.; Stiteler, Christopher J.; Venditto, Vincent J.; Krovic, Brooke; Hoffman, Christopher M.; Ondisco, Matthew T.; Belowich, Matthew E.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11590 - 11596
反应条件
resolving agent: trans-cellulose tris(4-phenylazophenylcarbamate) ( CPAPC ) adsorbed on silica gel; optical resolution degree examined by HPLC on cis/trans-CPAPC;
参考文献
RUDJER BOSKOVIC INSTITUTE
Patent: WO2009/109792 A1, 2009 ;
Location in patent: Page/Page column 16; Figure 5 ;
反应条件
1: 1,2-dichloro-ethane / 120 h / 45 - 50 °C / |Resolution of racemate 2: sodium carbonate / dichloromethane; water View Scheme
参考文献
Jameson, Donald L.; Field, Thomas; Schmidt, Monica R.; Destefano, Alyson K.; Stiteler, Christopher J.; Venditto, Vincent J.; Krovic, Brooke; Hoffman, Christopher M.; Ondisco, Matthew T.; Belowich, Matthew E.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11590 - 11596
反应条件
sodium hydroxide in 1,4-dioxane
Ambient temperature;
参考文献
Miyahara, Yuji; Izumi, Kenji; Ibrahim, Alhussein A.; Inazu, Takahiko
Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1705 - 1708
反应条件
1: aqueous NaOH
2: aqueous NaOH
View Scheme
参考文献
Cooper; Partridge
Journal of the Chemical Society, 1957 , p. 2888,2891
