2,3-二氢-1H-吲哚-3-羧酸甲酯合成路线 （共 6 条）
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran; methanol T=25°C; 2: With hydrogenchloride in water Acidic aqueous solution;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/103552 A1, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
hydrogen; 5-palladium/activated carbon in methanol; ethyl acetate
P=3102.97 Torr; 72 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/103552 A1, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
1: 95 percent / NaH / tetrahydrofuran
2: 68 percent / H2 / 5 percent Pd/C / methanol; ethyl acetate / 120 h / 20 °C / 5688.63 Torr
View Scheme
参考文献
O'Dell, David K.; Nicholas, Kenneth M.
Tetrahedron, 2003 , vol. 59, # 6 p. 747 - 754
反应条件
1: 95 percent / NaH / tetrahydrofuran
2: 68 percent / H2 / 5 percent Pd/C / methanol; ethyl acetate / 120 h / 20 °C / 5688.63 Torr
View Scheme
参考文献
O'Dell, David K.; Nicholas, Kenneth M.
Tetrahedron, 2003 , vol. 59, # 6 p. 747 - 754
反应条件
1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: magnesium / methanol; dichloromethane / Inert atmosphere
View Scheme
参考文献
Pietruszka, Joerg; Simon, Robert Christian
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14534 - 14544
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Pietruszka, Joerg; Simon, Robert Christian
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14534 - 14544
