5,5''-二氯-2',5'-二氢-2,2''-二甲基-3,3':4',3''-三联噻吩合成路线 （共 6 条）
反应条件
titanium tetrachloride; zinc in tetrahydrofuran
T=20°C; McMurry coupling; 48 h;
参考文献
Chen, Yi; Zeng, De X.; Fan, Mei G.
Organic Letters, 2003 , vol. 5, # 9 p. 1435 - 1437
反应条件
1.1: 82 percent / N-chlorosuccinimide / benzene; acetic acid / 7 h / 80 °C
2.1: AlCl3 / CH2Cl2 / 0.5 h / 0 °C
2.2: 78 percent / CH2Cl2 / 9 h / 0 - 20 °C
3.1: 53 percent / Br2 / CHCl3 / 12 h
4.1: 65 percent / Na2S / ethanol / 1 h / 20 °C
5.1: 70 percent / TiCl4; Zn powder / tetrahydrofuran / 48 h / 20 °C
View Scheme
参考文献
Chen, Yi; Zeng, De X.; Fan, Mei G.
Organic Letters, 2003 , vol. 5, # 9 p. 1435 - 1437
反应条件
1.1: AlCl3 / CH2Cl2 / 0.5 h / 0 °C
1.2: 78 percent / CH2Cl2 / 9 h / 0 - 20 °C
2.1: 53 percent / Br2 / CHCl3 / 12 h
3.1: 65 percent / Na2S / ethanol / 1 h / 20 °C
4.1: 70 percent / TiCl4; Zn powder / tetrahydrofuran / 48 h / 20 °C
View Scheme
参考文献
Chen, Yi; Zeng, De X.; Fan, Mei G.
Organic Letters, 2003 , vol. 5, # 9 p. 1435 - 1437
反应条件
1: 53 percent / Br2 / CHCl3 / 12 h
2: 65 percent / Na2S / ethanol / 1 h / 20 °C
3: 70 percent / TiCl4; Zn powder / tetrahydrofuran / 48 h / 20 °C
View Scheme
参考文献
Chen, Yi; Zeng, De X.; Fan, Mei G.
Organic Letters, 2003 , vol. 5, # 9 p. 1435 - 1437
反应条件
1: 65 percent / Na2S / ethanol / 1 h / 20 °C
2: 70 percent / TiCl4; Zn powder / tetrahydrofuran / 48 h / 20 °C
View Scheme
参考文献
Chen, Yi; Zeng, De X.; Fan, Mei G.
Organic Letters, 2003 , vol. 5, # 9 p. 1435 - 1437
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-50°C; 0.5 h;
2: With iodine in tetrahydrofuran; hexane
T=-78 - -20°C;
参考文献
Xie, Nan; Zeng, De Xing; Chen, Yi
Synlett, 2006 , # 5 p. 737 - 740
