反应条件
1: 100 percent / CBr4, PPh3 / tetrahydrofuran / 2 h
2: diisobutylaluminum hydride (DIBAL) / CH2Cl2; hexane / 0.5 h / -78 °C
3: 1.) lithium diisopropylamide (LDA) / 1.) THF, 0 deg C, 10 min, 2.) THF, hexane, 0 deg C, 1 h
4: 1.) n-butyllithium / 1.) THF, hexane, -23 deg C, 80 min, 2.) THF, hexane, 5 min
5: 1.) KH, 2.) tetrabutylammonium chloride, 18-crown-6 / 1.) THF, 15 min, 2.) THF, RT, 20 min
6: 86 percent / sodium naphthalenide / 1,2-dimethoxy-ethane / 0.67 h / -78 °C
7: 99 percent / K2CO3 / tetrahydrofuran; toluene
8: 85 percent / MeI, H2O / acetonitrile / Ambient temperature
9: 1.) t-BuLi, 2.) dineopentylzinc
10: (CH3)2SO, pyridine, CF3COOH, dicyclohexylcarbodiimide (DCC) / benzene / 0.5 h / Ambient temperature
11: benzene; diethyl ether / 0.33 h
12: n-Bu4NF / tetrahydrofuran / 0.25 h / 0 °C
13: 75percent aq. CH3COOH / tetrahydrofuran / 0 - 5 °C
14: 68 percent / diethyl cyanophosphonate, Et3N / dimethylformamide / 0.5 h / 0 °C
15: 86 percent / (COCl)2, (CH3)2SO / CH2Cl2 / 0.33 h / -78 °C
16: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 2.5 h / 0 °C
17: 100 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), H2O / CH2Cl2 / 0.5 h / Ambient temperature
18: 64 percent / CF3COOH / 2.5 h / Ambient temperature
View Scheme
参考文献
Smith III; Rano; Chida; Sulikowski; Wood
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 8008 - 8022
